Studies the basic concepts of mammalian cellular biology and biochemistry including the biosynthesis of proteins, nucleic acid structure and function in gene expression at the cellular level in both normal and disease states. Classification of enzymes and coenzymes, enzyme kinetics and regulation, drug biotransformation, drug receptor properties, fundamentals of pattern recognition that relate chemical structure to pharmacological action, membrane structure and transport, and mechanisms of signal transduction. Examines the basic concepts and principles of mammalian metabolic biochemistry including chemistry, biosynthesis and metabolism of carbohydrates, lipids and amino acids at the cellular level in normal and disease states. Principles of energy transformation are also studied