Course Description:

            Pharmacogenomics— use of genetic data to improve prediction of a patient’s responses to drugs while avoiding adverse drug reactions— is now recognized as an important sub-discipline in the precision medicine. All Pharmacy-associated organizations advocate for pharmacists playing key role in the implementation of pharmacogenomics in the practice of precision medicine. The ACPE Standards mandates that pharmacogenomics should be an integral part of the PharmD curriculum.  Importantly, the availability of pharmacogenomic testing kits in Rite Aid Pharmacies clearly indicates that an in-depth pharmacogenomics knowledge is essential for all pharmacists including retail pharmacists.

 This course addresses crucial concepts of genetics-disease relationships; genetics-drug metabolism relationships and principles underlying foundational methodologies of molecular biology and bioinformatics important for pharmacogenomics.  The course wraps up with the introduction of online resources of genomic technologies useful for pharmacists to practice pharmacogenomics in clinic and retail pharmacy.

 Course Goals and Objectives

The goals of this course are to highlight:

• Genetic basis for disease and drug action

• Genetic basis for alteration of drug metabolism

• Technologies of genome, bioinformatics and proteomics necessary for practicing pharmacogenomics

 Objectives of this course are that students completing this course will gain a better understanding of how genetic differences can impact the outcome of drug therapy. Students enrolled in this course will be exposed to knowledge on pharmacogenomics technologies and be able to interpret pharmacogenomics test results.    

 The course delivery will utilize formal PowerPoint presentations, case studies, Active Learnings and in silico analysis of genome databases.